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and the most common subtypes like CD66a, CD66b, CD66c, CD66d, CD66e, CD66f and CD66+

CD66a - Cluster of differentiation 66a

CD66a Gene ID 634
CD66a Official Full Name carcinoembryonic antigen related cell adhesion molecule 1
CD66a Alias BGP-1, NCA-160, CEACAM1
CD66a Cellular Expression Epithelial; Granulocyte
CD66a Ligand/Receptor/Association CD66a, c, e, CD62E, Opa
CD66a Function Neutrophil activation, homophilic and heterophilic adhesion
CD66a Summary This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]


CD66b - Cluster of differentiation 66b

CD66b Gene ID 1088
CD66b Official Full Name carcinoembryonic antigen related cell adhesion molecule 8
CD66b Alias CD67, CGM6, CEACAM8
CD66b Cellular Expression Granulocyte
CD66b Ligand/Receptor/Association CD66c
CD66b Function Cell adhesion and neutrophil activation
CD66b Summary The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]


CD66c - Cluster of differentiation 66c

CD66c Gene ID 4680
CD66c Official Full Name carcinoembryonic antigen related cell adhesion molecule 6
CD66c Alias NCA, CEACAM6
CD66c Cellular Expression Epithelial; Granulocyte
CD66c Ligand/Receptor/Association CD66a, b, c, e
CD66c Function Cell adhesion and neutrophil activation
CD66c Summary This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]


CD66d - Cluster of differentiation 66d

CD66d Gene ID 1084
CD66d Official Full Name carcinoembryonic antigen related cell adhesion molecule 3
CD66d Alias CGM1, CEACAM3
CD66d Cellular Expression Granulocyte
CD66d Ligand/Receptor/Association Opa I
CD66d Function Cell adhesion and neutrophil activation
CD66d Summary This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]


CD66e - Cluster of differentiation 66e

CD66e Gene ID 1048
CD66e Official Full Name carcinoembryonic antigen related cell adhesion molecule 5
CD66e Alias CEA, CEACAM5
CD66e Cellular Expression Epithelial
CD66e Ligand/Receptor/Association CD66a, c, e, Opa, CD62E
CD66e Function Homophilic and heterophilic adhesion. May play a role in the metastasis of cancer cells
CD66e Summary This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]


CD66f - Cluster of differentiation 66f

CD66f Gene ID 5669
CD66f Official Full Name pregnancy specific beta-1-glycoprotein 1
CD66f Alias PSG1, Sp-1, PSBG1
CD66f Cellular Expression Epithelial
CD66f Ligand/Receptor/Association
CD66f Function Cell adhesion, cellular migration, pathogen binding and activation of signaling pathways
CD66f Summary The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009]


All relevant products for CD66a, CD66b, CD66c, CD66d, CD66e, CD66f and CD66+

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