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CD59

and the most common subtypes like CD59a, CD59b and CD59+

CD59a - Cluster of differentiation 59

CD59 Gene ID 966
CD59 Official Full Name CD59 molecule
CD59 Alias Protectin, MAC- inhibitor
CD59 Cellular Expression T; NK; Erythrocyte; Granulocyte; Macrophage
CD59 Ligand/Receptor/Association C8a, C9
CD59 Function Prevents complement polymerization. Protects cells from complement mediated lysis
CD59 Summary CD59 glycoprotein also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene.[1]CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex.[2] Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria.[3]Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.[4

 

CD59a - Cluster of differentiation 59a

CD59a Gene ID 12509
CD59a Official Full Name CD59a antigen
CD59a Alias  
CD59a Cellular Expression  
CD59a Ligand/Receptor/Association  
CD59a Function  
CD59a Summary  

 

CD59b - Cluster of differentiation 59b

CD79b Gene ID 974
CD79b Official Full Name CD79b molecule
CD79b Alias B29, IGB, Ig-beta
CD79b Cellular Expression B
CD79b Ligand/Receptor/Association  
CD79b Function Subunit of B-cell antigen receptor.Signal transduction
CD79b Summary The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

 

All relevant products for CD59a, CD59b and CD59+

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