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CD167

and the most common subtypes like CD167a, CD167b and CD167+

CD167a - Cluster of differentiation 167a

CD167a Gene ID 780
CD167a Official Full Name discoidin domain receptor tyrosine kinase 1
CD167a Alias DDR1, MCK10
CD167a Cellular Expression B; Dendritic; Epithelial
CD167a Ligand/Receptor/Association collagen
CD167a Function Receptor tyrosine kinase involved in cell-cell interactions
CD167a Summary Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

 

CD167b - Cluster of differentiation 167b

CD167b Gene ID 4921
CD167b Official Full Name discoidin domain receptor tyrosine kinase 2
CD167b Alias DDR2
CD167b Cellular Expression 0
CD167b Ligand/Receptor/Association
CD167b Function Receptor tyrosine kinase involved in cell-cell interactions
CD167b Summary Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

 

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