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and the most common subtypes like CD32a, CD32b and CD32+

CD32 - Cluster of differentiation 32

CD32 Gene ID  
CD32 Official Full Name  
CD32 Alias FCG2, FCGR2A1, FCGR2
CD32 Cellular Expression T; B; Endothelial; Dendritic cell; Granulocyte; Macrophage; monocytes
CD32 Ligand/Receptor/Association aggregated IgG, phosphatases
CD32 Function Regulation of B-cell function. Induces phagocytosis and mediator release.
CD32 Summary CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling. It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loop acts to lower the production of IgG by B cells when there is a surplus in the body.


CD32a - Cluster of differentiation 32a

CD32a Gene ID 2212
CD32a Official Full Name Fc fragment of IgG receptor IIa
CD32a Alias FcγRII, FCGR2A,Fc gamma RIIA
CD32a Cellular Expression B; Dendritic; Granulocyte; Macrophage; Platelet
CD32a Ligand/Receptor/Association 0
CD32a Function Innate and adaptive immune responses
CD32a Summary This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]


CD32b - Cluster of differentiation 32b

CD32b Gene ID 14130
CD32b Official Full Name Fc receptor, IgG, low affinity IIb
CD32b Alias FcγRII, FCGR2B,Fc gamma RIIB
CD32b Cellular Expression T; B; Endothelial; Granulocyte; Macrophage; Platelet
CD32b Ligand/Receptor/Association  
CD32b Function Phagocytosis of immune complexes and regulation of antibody production
CD32b Summary This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]


All relevant products for CD32a, CD32b and CD32+

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11 Artikel