|CD122 Gene ID||3560|
|CD122 Official Full Name||interleukin 2 receptor subunit beta|
|CD122 Alias||IL-2Rβ, IL-2RB|
|CD122 Cellular Expression||T; B; NK; Macrophage; monocytes|
|CD122 Ligand/Receptor/Association||IL-2, IL-15|
|CD122 Function||Receptor for IL2 and IL15|
|CD122 Summary||The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]|
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