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CD279
and the most popular subtypes like CD279+
| CD279 Gene ID | 5133 |
|---|---|
| CD279 Official Full Name | programmed cell death 1 |
| CD279 Alias | PD1, SLEB2 |
| CD279 Cellular Expression | T; B |
| CD279 Ligand/Receptor/Association | CD273, CD274 |
| CD279 Function | Inhibitory cell surface receptor involved in T-cell tolerance |
| CD279 Summary | This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008] |
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