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CD121
and the most common subtypes like CD121a, CD121b and CD121+
CD8a - Cluster of differentiation 121a
| CD121a Gene ID | 16177 |
|---|---|
| CD121a Official Full Name | interleukin 1 receptor, type I |
| CD121a Alias | IL-1R type I, IL1R1, IL1R1, IL-1 RI |
| CD121a Cellular Expression | T; Dendritic; Endothelial; Epithelial; Granulocyte; Macrophage; monocytes |
| CD121a Ligand/Receptor/Association | IL-1��, IL-1��, IL-1RA |
| CD121a Function | Receptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling |
| CD121a Summary | Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.[1] The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.[1] |
CD121b - Cluster of differentiation 121b
| CD121b Gene ID | 7850 |
|---|---|
| CD121b Official Full Name | interleukin 1 receptor type 2 |
| CD121b Alias | IL-1R, type II, IL1R2, IL-1R2 |
| CD121b Cellular Expression | T; B; Macrophage; monocytes |
| CD121b Ligand/Receptor/Association | IL-1��, IL-1��, IL-1RA |
| CD121b Function | Receptor for IL1A, IL1B and IL1RN. Mediates IL1 signaling |
| CD121b Summary | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012] |
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