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CD132
and the most popular subtypes like CD132+
| CD130 Gene ID | 3572 |
|---|---|
| CD130 Official Full Name | interleukin 6 signal transducer |
| CD130 Alias | IL-6Rβ, gp130, IL6ST |
| CD130 Cellular Expression | T; B; NK; Endothelial; Epithelial; Granulocyte; Macrophage; monocytes; Stem cell |
| CD130 Ligand/Receptor/Association | |
| CD130 Function | Transmits activities of IL6, IL11, LIF and CNF |
| CD130 Summary | The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014] |
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