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CD114
and the most popular subtypes like CD114+
| CD114 Gene ID | 1441 |
|---|---|
| CD114 Official Full Name | colony stimulating factor 3 receptor |
| CD114 Alias | GCSFR, CSF3R |
| CD114 Cellular Expression | Endothelial; Granulocyte; Macrophage; Platelet; Stem cell |
| CD114 Ligand/Receptor/Association | G-CSF |
| CD114 Function | Myeloid cell proliferation and differentiation |
| CD114 Summary | The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene.[1] G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF).[2] The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family.The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. |
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