Profile Informationen
Login Daten
oder Einloggen
CD66a Gene ID | 634 |
---|---|
CD66a Official Full Name | carcinoembryonic antigen related cell adhesion molecule 1 |
CD66a Alias | BGP-1, NCA-160, CEACAM1 |
CD66a Cellular Expression | Epithelial; Granulocyte |
CD66a Ligand/Receptor/Association | CD66a, c, e, CD62E, Opa |
CD66a Function | Neutrophil activation, homophilic and heterophilic adhesion |
CD66a Summary | This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010] |
CD66b Gene ID | 1088 |
---|---|
CD66b Official Full Name | carcinoembryonic antigen related cell adhesion molecule 8 |
CD66b Alias | CD67, CGM6, CEACAM8 |
CD66b Cellular Expression | Granulocyte |
CD66b Ligand/Receptor/Association | CD66c |
CD66b Function | Cell adhesion and neutrophil activation |
CD66b Summary | The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008] |
CD66c Gene ID | 4680 |
---|---|
CD66c Official Full Name | carcinoembryonic antigen related cell adhesion molecule 6 |
CD66c Alias | NCA, CEACAM6 |
CD66c Cellular Expression | Epithelial; Granulocyte |
CD66c Ligand/Receptor/Association | CD66a, b, c, e |
CD66c Function | Cell adhesion and neutrophil activation |
CD66c Summary | This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014] |
CD66d Gene ID | 1084 |
---|---|
CD66d Official Full Name | carcinoembryonic antigen related cell adhesion molecule 3 |
CD66d Alias | CGM1, CEACAM3 |
CD66d Cellular Expression | Granulocyte |
CD66d Ligand/Receptor/Association | Opa I |
CD66d Function | Cell adhesion and neutrophil activation |
CD66d Summary | This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013] |
CD66e Gene ID | 1048 |
---|---|
CD66e Official Full Name | carcinoembryonic antigen related cell adhesion molecule 5 |
CD66e Alias | CEA, CEACAM5 |
CD66e Cellular Expression | Epithelial |
CD66e Ligand/Receptor/Association | CD66a, c, e, Opa, CD62E |
CD66e Function | Homophilic and heterophilic adhesion. May play a role in the metastasis of cancer cells |
CD66e Summary | This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] |
CD66f Gene ID | 5669 |
---|---|
CD66f Official Full Name | pregnancy specific beta-1-glycoprotein 1 |
CD66f Alias | PSG1, Sp-1, PSBG1 |
CD66f Cellular Expression | Epithelial |
CD66f Ligand/Receptor/Association | |
CD66f Function | Cell adhesion, cellular migration, pathogen binding and activation of signaling pathways |
CD66f Summary | The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009] |