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CD32 Gene ID | |
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CD32 Official Full Name | |
CD32 Alias | FCG2, FCGR2A1, FCGR2 |
CD32 Cellular Expression | T; B; Endothelial; Dendritic cell; Granulocyte; Macrophage; monocytes |
CD32 Ligand/Receptor/Association | aggregated IgG, phosphatases |
CD32 Function | Regulation of B-cell function. Induces phagocytosis and mediator release. |
CD32 Summary | CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling. It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loop acts to lower the production of IgG by B cells when there is a surplus in the body. |
CD32a Gene ID | 2212 |
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CD32a Official Full Name | Fc fragment of IgG receptor IIa |
CD32a Alias | FcγRII, FCGR2A,Fc gamma RIIA |
CD32a Cellular Expression | B; Dendritic; Granulocyte; Macrophage; Platelet |
CD32a Ligand/Receptor/Association | 0 |
CD32a Function | Innate and adaptive immune responses |
CD32a Summary | This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008] |
CD32b Gene ID | 14130 |
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CD32b Official Full Name | Fc receptor, IgG, low affinity IIb |
CD32b Alias | FcγRII, FCGR2B,Fc gamma RIIB |
CD32b Cellular Expression | T; B; Endothelial; Granulocyte; Macrophage; Platelet |
CD32b Ligand/Receptor/Association | |
CD32b Function | Phagocytosis of immune complexes and regulation of antibody production |
CD32b Summary | This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] |