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CD2 Gene ID | 914 |
---|---|
CD2 Official Full Name | CD2 molecule |
CD2 Alias | T11, LFA-2, SRBC-R, Erythrocyte receptor, LFA-3R |
CD2 Cellular Expression | T; B; NK; monocytes |
CD2 Ligand/Receptor/Association | CD58, CD59 and CD15 |
CD2 Function | Adhesion between T-cells and other cell types and T-cell activation. |
CD2 Summary | CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010] |