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CD38
and the most popular subtypes like CD38+
| CD38 Gene ID | 952 |
|---|---|
| CD38 Official Full Name | CD38 molecule |
| CD38 Alias | T10, ADPRC1, ADP ribosyl cyclase 1 |
| CD38 Cellular Expression | T; B; NK; Dendritic; Macrophage; Stem cell |
| CD38 Ligand/Receptor/Association | CD31 |
| CD38 Function | Cell adhesion and signal transduction |
| CD38 Summary | The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
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