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CD35
and the most popular subtypes like CD35+
| CD35 Gene ID | 1378 |
|---|---|
| CD35 Official Full Name | complement component 3b/4b receptor 1 (Knops blood group) |
| CD35 Alias | CR1, C3b/C4b receptor |
| CD35 Cellular Expression | T; B; Dendritic; Erythrocyte; Granulocyte; Macrophage; monocytes |
| CD35 Ligand/Receptor/Association | C3b, C4b, iC3, iC4 |
| CD35 Function | Receptor for complement components C3b and C4b. Mediates adhesion and phagocytosis |
| CD35 Summary | This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008] |
