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CD50 Gene ID | 3385 |
---|---|
CD50 Official Full Name | intercellular adhesion molecule 3 |
CD50 Alias | ICAM-3 |
CD50 Cellular Expression | T; B; NK; Endothelial; Granulocyte; Macrophage; Stem cell |
CD50 Ligand/Receptor/Association | CD11a/CD18 |
CD50 Function | Adhesion and costimulation |
CD50 Summary | The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016] |