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CD4 Gene ID | 920 |
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CD4 Official Full Name | CD4 molecule |
CD4 Alias | T4 |
CD4 Cellular Expression | T; Granulocyte; Macrophage; monocytes |
CD4 Ligand/Receptor/Association | MHC class II, HIV gp120, IL-16 |
CD4 Function | T-cell activation, thymic differentiation and receptor for HIV |
CD4 Summary | This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010] |