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CD334 Gene ID | 2264 |
---|---|
CD334 Official Full Name | fibroblast growth factor receptor 4 |
CD334 Alias | FGFR4, JTK2, TKF |
CD334 Cellular Expression | Epithelial; Macrophage |
CD334 Ligand/Receptor/Association | aFGF, FGF19 |
CD334 Function | Cell-surface receptor for fibroblast growth factors |
CD334 Summary | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |