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CD27 Gene ID | 939 |
---|---|
CD27 Official Full Name | CD27 molecule |
CD27 Alias | T14, TNFRSF 7, CD27L receptor |
CD27 Cellular Expression | T; B; NK |
CD27 Ligand/Receptor/Association | CD70 |
CD27 Function | Costimulation of B- and T-cell activation |
CD27 Summary | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008] |