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CD261 Gene ID | 8797 |
---|---|
CD261 Official Full Name | tumor necrosis factor receptor superfamily member 10a |
CD261 Alias | TRAIL-R1, DR4, TNFRSF10A |
CD261 Cellular Expression | T; B; NK; Granulocyte; Macrophage |
CD261 Ligand/Receptor/Association | TRAIL (CD253) |
CD261 Function | Induces apoptosis, promotes activation of NFkB |
CD261 Summary | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008] |