Profile Informationen
Login Daten
oder Einloggen
CD152 Gene ID | 1493 |
---|---|
CD152 Official Full Name | cytotoxic T-lymphocyte associated protein 4 |
CD152 Alias | CTLA-4 |
CD152 Cellular Expression | T; B |
CD152 Ligand/Receptor/Association | CD86, CD80 |
CD152 Function | T-cell inhibition |
CD152 Summary | This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008] |