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CD120a Gene ID | 7132 |
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CD120a Official Full Name | tumor necrosis factor receptor superfamily member 1A |
CD120a Alias | TNFR-I, TNFRSF1A, TNFR1 |
CD120a Cellular Expression | T; B; NK; Dendritic; Endothelial; Epithelial; Granulocyte; Macrophage |
CD120a Ligand/Receptor/Association | TNF-�� and TNF-�� |
CD120a Function | Receptor for TNF |
CD120a Summary | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008] |
CD120b Gene ID | 21938 |
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CD120b Official Full Name | tumor necrosis factor receptor superfamily, member 1b |
CD120b Alias | TNFR-II, TNFRSF1B, TNFR2 |
CD120b Cellular Expression | T; B; NK; Dendritic; Endothelial; Epithelial; Granulocyte; Macrophage |
CD120b Ligand/Receptor/Association | TNF-�� and TNF-�� |
CD120b Function | Receptor for TNF. Involved in cell differentiation, apoptosis and necrosis |
CD120b Summary | Tumor necrosis factor receptor superfamily member 1B (TNFR2), encoded by TNFRSF1B gene. Constituent of the drug Enbrel, used to treat rheumatoid arthritis. |