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CD111 Gene ID | 58235 |
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CD111 Official Full Name | poliovirus receptor-related 1 |
CD111 Alias | PVRL1, PRR1, Nectin-1, HVEC |
CD111 Cellular Expression | Endothelial; Epithelial; Erythrocyte; Macrophage; Platelet; Stem cell |
CD111 Ligand/Receptor/Association | nectin-3, Afadin, HSVgD |
CD111 Function | Entry mediator for several herpes viruses (HSV1, HSV2, PRV, BHV1).Believed to be involved in cell adhesion mechanisms |
CD111 Summary | Poliovirus receptor-related 1 (PVRL1), also known as nectin-1 and CD111 (formerly herpesvirus entry mediator C, HVEC) is a human protein of the immunoglobulin superfamily (IgSF), also considered a member of the nectins.[1] It is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail. The protein can mediate Ca2+-independent cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM). |