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CD1b Gene ID | 910 |
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CD1b Official Full Name | CD1b molecule |
CD1b Alias | T6 |
CD1b Cellular Expression | T; B; Dendritic; Macrophage |
CD1b Ligand/Receptor/Association | CD1-restricted TCR |
CD1b Function | Antigen presenting protein |
CD1b Summary | This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008] |
CD1c Gene ID | 911 |
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CD1c Official Full Name | CD1c molecule |
CD1c Alias | R7, CD1, CD1A, BDCA1 |
CD1c Cellular Expression | T; B; Dendritic |
CD1c Ligand/Receptor/Association | CD1-restricted TCR |
CD1c Function | Non peptide antigen presentation to T-cell receptors on NKT cells. |
CD1c Summary | This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008] |
CD1d Gene ID | 912 |
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CD1d Official Full Name | CD1d molecule |
CD1d Alias | R3G1 |
CD1d Cellular Expression | T; B; Dendritic; Epithelial |
CD1d Ligand/Receptor/Association | CD1-restricted TCR |
CD1d Function | Antigen presenting protein |
CD1d Summary | This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] |