CD68

and the most popular subtypes like CD68+

CD68 Gene ID	968
CD68 Official Full Name	CD68 molecule
CD68 Alias	Macrosialin, gp110, KP1
CD68 Cellular Expression	Dendritic; Epithelial; monocytes
CD68 Ligand/Receptor/Association	oxidized LDL
CD68 Function	Macrophage homing
CD68 Summary	This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

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