CD167

and the most common subtypes like CD167a, CD167b and CD167+

CD167a Gene ID	780
CD167a Official Full Name	discoidin domain receptor tyrosine kinase 1
CD167a Alias	DDR1, MCK10
CD167a Cellular Expression	B; Dendritic; Epithelial
CD167a Ligand/Receptor/Association	collagen
CD167a Function	Receptor tyrosine kinase involved in cell-cell interactions
CD167a Summary	Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

CD167b Gene ID	4921
CD167b Official Full Name	discoidin domain receptor tyrosine kinase 2
CD167b Alias	DDR2
CD167b Cellular Expression	0
CD167b Ligand/Receptor/Association
CD167b Function	Receptor tyrosine kinase involved in cell-cell interactions
CD167b Summary	Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]