CD283

and the most popular subtypes like CD283+

CD283 Gene ID	7098
CD283 Official Full Name	toll like receptor 3
CD283 Alias	TLR3
CD283 Cellular Expression	T; B; Dendritic; Epithelial
CD283 Ligand/Receptor/Association	dsRNA
CD283 Function	Mediator of innate immunity against viral infection, activated by dsDNA
CD283 Summary	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]

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