CD281

and the most popular subtypes like CD281+

CD281 Gene ID	7096
CD281 Official Full Name	toll like receptor 1
CD281 Alias	TLR1
CD281 Cellular Expression	Dendritic; Granulocyte; Macrophage; monocytes
CD281 Ligand/Receptor/Association	lipoproteins
CD281 Function	Pathogen recognition and activation of innate immunity, regulates TLR2 function
CD281 Summary	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

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