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CD11
and the most common subtypes like CD11a, CD11b, CD11c and CD11+
CD11a - Cluster of differentiation 11a
| CD11a Gene ID | 3683 |
|---|---|
| CD11a Official Full Name | integrin subunit alpha L |
| CD11a Alias | LFA-1, LFA1A, ITGAL |
| CD11a Cellular Expression | T; B; NK; Dendritic; Granulocyte; Macrophage; monocytes |
| CD11a Ligand/Receptor/Association | CD54, CD102, CD50, and CD242 |
| CD11a Function | Intracellular adhesion and costimulation. |
| CD11a Summary | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
CD11b - Cluster of differentiation 11b
| CD11b Gene ID | 3684 |
|---|---|
| CD11b Official Full Name | integrin subunit alpha M |
| CD11b Alias | ITGAM, CR3A, MO1A, MAC-1, MAC1A, SLEB6 |
| CD11b Cellular Expression | T; B; NK; Dendritic; Macrophage; monocytes |
| CD11b Ligand/Receptor/Association | CD54, iC3b and ECM , CD242 |
| CD11b Function | cell adhesion, and immune response |
| CD11b Summary | This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] |
CD11c - Cluster of differentiation 11c
| CD11c Gene ID | 3687 |
|---|---|
| CD11c Official Full Name | integrin subunit alpha X |
| CD11c Alias | p150, 95, CR4, integrin alpha X, LFA-1A, ITGAX |
| CD11c Cellular Expression | T; B; NK; Dendritic; Granulocyte; Macrophage; monocytes |
| CD11c Ligand/Receptor/Association | iC3b, ECM |
| CD11c Function | Cell adhesion |
| CD11c Summary | This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
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