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Tumor necrosis factor (TNF)
Find your tumor necrosis factor
What is Tumor Necrosis Factor (TNF)
Tumor necrosis factors (TNF family) refer to a group of cytokines which are mainly secreted by macrophages and can induce cell death of certain tumor cell lines. The first two members of the family to be identified were: Tumor Necrosis Factor Alpha (TNF Alpha) and Tumor necrosis factor-beta (TNF-β), also known as Lymphotoxin-alpha, a cytokine that is inhibited by interleukin 10.
Tumor Necrosis Factor (TNF) Inhibitors
Tumor necrosis factor (TNF) promotes the inflammatory response, which in turn causes many of the clinical problems associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis, hidradenitis suppurativa and refractory asthma. These disorders are sometimes treated by using a TNF inhibitor, also known as TNF blocker.
Tumor Necrosis Factor (TNF) Signaling Pathway
The tumor necrosis factor (TNF) superfamily of cytokines activate signaling pathways for cell survival, death, and differentiation. Members of the tumor necrosis factor superfamily act through ligand-mediated trimerization, causing recruitment of several intracellular adaptors to activate multiple signal transduction pathways. Recruitment of death domain (DD) containing adaptors such as Fas associated death domain (FADD) and TNFR associated DD (TRADD) can lead to the activation of a signal transduction pathway that induces apoptosis. While recruitment of TRAF family proteins can lead to the activation of transcription factors such as, NF-kappaB and JNK thereby promoting cell survival and differentiation as well as immune and inflammatory responses.
Anti TNF Therapy / Anti TNF Drugs
Tumoral necrosis factor α plays a central role in both the inflammatory response and that of the immune system. Thus, its blockade with the so-called anti TNF drugs / agents has turned into the most important tool in the management of a variety of disorders, such as rheumatoid arthritis, spondyloarthropatties, inflammatory bowel disease, and psoriasis.
TNF relevant products:
Use the filter on the right or the search box below to find your product.
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Cow TNFa ELISA Kit - abx150208
Detection: 7.81 pg/ml - 500 pg/mlDowiedz się więcejProduct Code: abx150208 -
Cow TNFa ELISA Kit - abx576156
Sensitivity: > 3.2 pg/mlDowiedz się więcej
Detection: 78.125 pg/ml - 5000 pg/mlProduct Code: abx576156 -
Cow TNFb ELISA Kit - abx150209
Sensitivity: < 0.041 ng/mlDowiedz się więcej
Detection: 0.156 ng/ml - 10 ng/mlProduct Code: abx150209 -
Cow TNFb ELISA Kit - abx570498
Sensitivity: > 0.041 ng/mlDowiedz się więcej
Detection: 0.156 ng/ml - 10 ng/mlProduct Code: abx570498 -
Dog TNFa ELISA Kit - abx150297
Detection: 15.63 pg/ml - 1000 pg/mlDowiedz się więcejProduct Code: abx150297 -
Dog TNFa ELISA Kit - abx575336
Sensitivity: > 1.19 pg/mlDowiedz się więcej
Detection: 3.125 pg/ml - 200 pg/mlProduct Code: abx575336 -
Dog TNFb ELISA Kit
Sensitivity: > 3.6 ng/mlDowiedz się więcej
Detection: 15.625 ng/ml - 1000 ng/mlProduct Code: abx574365 -
Duck Tumor necrosis factor alpha (TNF alpha) ELISA Kit
Sensitivity: 0.1 pg/mlDowiedz się więcej
Detection: 1 pg/ml - 70 pg/mlProduct Code: abx055515 -
Ferret TNF-alpha / TNFA ELISA Pair Set
Sensitivity: The minimum detectable dose of Ferret CD4 / Leu-3 was determined to be approximately 31.25 pg/ml. This is defined as at least three times standard deviations above the mean optical density of 10 replicates of the zero standard.Dowiedz się więcej
Detection: 31.25 pg/ml -
Goat TNFa ELISA Kit - abx150405
Detection: 15.63 pg/ml - 1000 pg/mlDowiedz się więcejProduct Code: abx150405 -
Goat TNFa ELISA Kit - abx574749
Sensitivity: > 5.9 pg/mlDowiedz się więcej
Detection: 15.625 pg/ml - 1000 pg/mlProduct Code: abx574749 -
Guinea Pig TNFa ELISA Kit - abx150434
Detection: 15.63 pg/ml - 1000 pg/mlDowiedz się więcejProduct Code: abx150434 -
Guinea pig TNFa ELISA Kit - abx574606
Sensitivity: > 5.5 pg/mlDowiedz się więcej
Detection: 15.625 pg/ml - 1000 pg/mlProduct Code: abx574606 -
Horse TNFa ELISA Kit - abx150478
Detection: 7.81 pg/ml - 500 pg/mlDowiedz się więcejProduct Code: abx150478 -
Horse TNFa ELISA Kit - abx575545
Sensitivity: > 13.4 pg/mlDowiedz się więcej
Detection: 31.25 pg/ml - 2000 pg/mlProduct Code: abx575545
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