CD152

and the most popular subtypes like CD152+

CD152 Gene ID	1493
CD152 Official Full Name	cytotoxic T-lymphocyte associated protein 4
CD152 Alias	CTLA-4
CD152 Cellular Expression	T; B
CD152 Ligand/Receptor/Association	CD86, CD80
CD152 Function	T-cell inhibition
CD152 Summary	This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]