CD118

and the most popular subtypes like CD118+

CD118 Gene ID	3977
CD118 Official Full Name	leukemia inhibitory factor receptor alpha
CD118 Alias	LIFR, gp190
CD118 Cellular Expression	Epithelial; monocytes
CD118 Ligand/Receptor/Association	LIF, OSM, CNTF, CT1
CD118 Function	Regulates a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion
CD118 Summary	This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]