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CD105
and the most popular subtypes like CD105+
CD105 Gene ID
2022
CD105 Official Full Name
endoglin
CD105 Alias
Endoglin, ENG, END
CD105 Cellular Expression
Endothelial; Macrophage; monocytes; Stem cell
CD105 Ligand/Receptor/Association
TGF-��1, TGF-��3
CD105 Function
Angiogenesis. Regulatory component of TGF-beta receptor complex.Modulates cellular response to TGF beta 1
CD105 Summary
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Sensitivity: The minimum detectable dose of Human Complement Component C2 was determined to be approximately 78.125 pg/ml. This is defined as at least three times standard deviations above the mean optical density of 10 replicates of the zero standard. Detection: 78.125 pg/ml
Sensitivity: The minimum detectable dose of Mouse CD48 / SLAMF2 / BCM1 was determined to be approximately 62.5 pg/ml. This is defined as at least three times standard deviations above the mean optical density of 10 replicates of the zero standard. Detection: 62.5 pg/ml