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CD47 Gene ID | 16423 |
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CD47 Official Full Name | CD47 antigen (Rh-related antigen, integrin-associated signal transducer) |
CD47 Alias | IAP, MER6 |
CD47 Cellular Expression | T; B; NK; Endothelial; Epithelial; Erythrocyte; Granulocyte; Macrophage; Platelet |
CD47 Ligand/Receptor/Association | CD172a, CD172g |
CD47 Function | Cell adhesion and signal transduction |
CD47 Summary | CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily[1] and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP��).[2] CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells.[2][3] |