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CD253
and the most popular subtypes like CD253+
| CD253 Gene ID | 8743 |
|---|---|
| CD253 Official Full Name | tumor necrosis factor superfamily member 10 |
| CD253 Alias | TRAIL, Apo-2L, TL2, TNFSF10 |
| CD253 Cellular Expression | T; B; NK; Macrophage |
| CD253 Ligand/Receptor/Association | DR4, DR5, DcR1, DcR2 |
| CD253 Function | Induces cell death by apoptosis |
| CD253 Summary | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
All relevant products for CD253 and CD253+
-
Trail / APO2L/CD253
Sensitivity: < 64 pg / mlLearn More
Detection: 93.75 pg / ml - 3000 pg / mlProduct Code: 850770192 -
Trail / APO2L/CD253
Sensitivity: < 15 pg / mlLearn More
Detection: 31.25 pg / ml - 1000 pg / mlProduct Code: 850770096
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