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CD15 Gene ID | 14345 |
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CD15 Official Full Name | fucosyltransferase 4 |
CD15 Alias | Lewis X (Lex), SSEA-1, 3-FAL |
CD15 Cellular Expression | Granulocyte |
CD15 Ligand/Receptor/Association | CD62E |
CD15 Function | Cell adhesion |
CD15 Summary | CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation antigen - an immunologically significant molecule. CD15 is a carbohydrate[1] adhesion molecule that can be expressed on glycoproteins, glycolipids and proteoglycans. CD15 mediates phagocytosis and chemotaxis, found on neutrophils; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias. It is also called Lewis x and SSEA-1 (stage-specific embryonic antigen 1) and represents a marker for murine pluripotent stem cells, in which it plays an important role in adhesion and migration of the cells in the preimplantation embryo. It is synthezised by FUT4 (fucosyltransferase 4) and FUT9. |