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Colony-stimulating factor (CSF)

Colony-stimulating factor

Granulocyte macrophage colony-stimulating factor (GM-CSF) Granulocyte-colony-stimulating factor (G-CSF) Macrophage colony-stimulating factor (M-CSF)

Colony-stimulating factors (CSFs) are secreted glycoproteins which regulate bone marrow production of circulating red and white cells, and platelets. Colony-stimulating factors bind to receptors on the surfaces of hemopoietic stem cells and thereby activate intracellular signaling pathways which induce the cells to proliferate and differentiate into a specific kind of blood cell. Colony-stimulating factors include: macrophage colony-stimulating factor (M-CSF), Granulocyte macrophage colony-stimulating factor (GM-CSF) and Granulocyte colony-stimulating factor (G-CSF).

 

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