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CD59
and the most common subtypes like CD59a, CD59b and CD59+
CD59a - Cluster of differentiation 59
| CD59 Gene ID | 966 |
|---|---|
| CD59 Official Full Name | CD59 molecule |
| CD59 Alias | Protectin, MAC- inhibitor |
| CD59 Cellular Expression | T; NK; Erythrocyte; Granulocyte; Macrophage |
| CD59 Ligand/Receptor/Association | C8a, C9 |
| CD59 Function | Prevents complement polymerization. Protects cells from complement mediated lysis |
| CD59 Summary | CD59 glycoprotein also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene.[1]CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex.[2] Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria.[3]Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.[4 |
CD59a - Cluster of differentiation 59a
| CD59a Gene ID | 12509 |
|---|---|
| CD59a Official Full Name | CD59a antigen |
| CD59a Alias | |
| CD59a Cellular Expression | |
| CD59a Ligand/Receptor/Association | |
| CD59a Function | |
| CD59a Summary |
CD59b - Cluster of differentiation 59b
| CD79b Gene ID | 974 |
|---|---|
| CD79b Official Full Name | CD79b molecule |
| CD79b Alias | B29, IGB, Ig-beta |
| CD79b Cellular Expression | B |
| CD79b Ligand/Receptor/Association | |
| CD79b Function | Subunit of B-cell antigen receptor.Signal transduction |
| CD79b Summary | The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
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