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VEGF Signaling

Vascular endothelial growth factors (VEGFs) constitute a sub-family of growth factors that stimulate the growth of new blood vessels. Vascular endothelial growth factors are important signaling proteins involved in both vasculogenesis (the de novo formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). VEGF-A is the first member of the vascular endothelial growth factor family, which also include VEGF-B, VEGF-C, VEGF-D, and placenta growth factor (PlGF). VEGF-A was called just VEGF before discovery of the other members. Vascular endothelial growth factors are key mediators of angiogenesis that is crucial for development and metastasis of tumors. The importance of VEGFs in tumorigenesis and tumor progression makes them attractive targets for the development of anticancer therapies. Previous studies have implicated single nucleotide polymorphisms (SNP) in the VEGF gene as predictive and prognostic markers for major solid tumors, including the breast, non-small cell lung, colorectal, and prostate cancers.

PIP3 PIP2 PTEN PI3K MKK3/6 Akt/PKB p38 MAPKAPK2/3 HSP27 FAK Paxillin MAPK MEK Raf Ras DAG PKC NO NOS Ca IP3 PIP2 PLC SOS GRB2 SHC VEGF-Receptor VEGF AKT signaling Cell survival Actin reorganization Cytoskeletal rearangement Cell migration Gen expression Cell proliferation Vascular cell permeability Cell proliferation Angiogenesis Prostaglandin production

VEGF Signaling from A to Z

Akt/PKB search result
Ca search result
FAK search result
GRB2 search result
HSP27 search result
IP3 search result
MAPK search result
MAPKAPK2/3 search result
MEK search result
MKK3/6 search result
NO search result
NOS search result
p38 search result
Paxillin search result
PI3K search result
PIP2 search result
PIP3 search result
PLC search result
PTEN search result
Raf search result
Ras search result
SHC search result
SOS search result
VEGF search result
VEGF-Receptor search result
DAG search result
PKC search result
AKT signaling search result
Cell survival search result
Actin reorganization search result
Cytoskeletal rearangement search result
Gen expression search result
Cell proliferation search result
Vascular cell permeability search result
Prostaglandin production search result
Angiogenesis search result
Cell migration search result

Thanks to Sino Biological for providing the pathways.