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CD8a Gene ID | 12525 |
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CD8a Official Full Name | CD8 antigen, alpha chain |
CD8a Alias | T8, Leu-2, MAL, CD8 alpha |
CD8a Cellular Expression | T; NK; Dendritic |
CD8a Ligand/Receptor/Association | MHC class I |
CD8a Function | Co-receptor for MHC class 1 molecules |
CD8a Summary | T-cell surface glycoprotein CD8 alpha chain. Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets |
CD8b Gene ID | 926 |
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CD8b Official Full Name | CD8b molecule |
CD8b Alias | CD8B1, P37 |
CD8b Cellular Expression | T |
CD8b Ligand/Receptor/Association | MHC class I |
CD8b Function | Co-receptor for MHC class 1 molecules |
CD8b Summary | The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010] |