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CD247 Gene ID | 919 |
---|---|
CD247 Official Full Name | CD247 molecule |
CD247 Alias | TCRz, CD3-ZEETA |
CD247 Cellular Expression | T; NK; Stem cell |
CD247 Ligand/Receptor/Association | |
CD247 Function | Couples antigen recognition to several intracellular signaling pathways |
CD247 Summary | The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |