|CD153 Gene ID||944|
|CD153 Official Full Name||tumor necrosis factor superfamily member 8|
|CD153 Alias||CD30L, TNFSF8|
|CD153 Cellular Expression||T; B; Granulocyte; Macrophage|
|CD153 Function||Binds to CD30 and induces proliferation of T-cells|
|CD153 Summary||The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]|
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