BioAim Scientific (Kanada)
The BioAim Rat Gastrin EasyTestTM Competitive ELISA kit can quantitatively measure Gastrin in rat serum or plasma. Other matrices, such as urine and tissue, may be suitable but have not been validated. It is a simple and rapid technology for the quantitation of antigen in a range of sample matrices. The whole process takes 2 hours with high accuracy and precision.Research Area Peptide hormone;
gastrin(Gastrin) Background: Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas. It is secreted into the bloodstream. Gastrin is found primarily in three forms: gastrin-34 (“big gastrin”), gastrin-17 (“little gastrin”), gastrin-14 (“minigastrin”). Gastrin binds to cholecystokinin B receptors to stimulate the release of histamines in enterochromaffin-like cells, and it induces the insertion of K+/H+ ATPase pumps into the apical membrane of parietal cells (which in turn increases H+ release into the stomach cavity). This is the major stimulus for acid secretion by parietal cells. Along with the above-mentioned function, gastrin has been shown to have additional functions as well: stimulates parietal cell maturation and fundal growth, Causes chief cells to secrete pepsinogen, the zymogen (inactive) form of the digestive enzyme pepsin, increases antral muscle mobility and promotes stomach contractions, strengthens antral contractions against the pylorus, and constricts the pyloric sphincter, which diminishes the rate of gastric emptying, plays a role in the relaxation of the ileocecal valve, induces pancreatic secretions and gallbladder emptying.
|Detection Range||2.4-10000 pg/ml|