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Notch Signaling Pathway

The Notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms. Notch signaling plays a pivotal role in the regulation of many fundamental cellular processes such as proliferation, stem cell maintenance and differentiation during embryonic and adult development. The notch cascade consists of notch and notch ligands, as well as intracellular proteins transmitting the notch signal to the cell's nucleus. In mammalian cells, there are four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4, which display both redundant and unique functions. Notch receptors are large single pass Type I transmembrane proteins. The extracellular domain of all Notch proteins contains 29–36 tandem epidermal growth factor (EGF)-like repeats, some of which mediate interactions with ligand. After specific ligand binding, the intracellular part of the Notch receptor is cleaved off and translocates to the nucleus, where it binds to the transcription factor RBP-J. In the absence of activated Notch, RBP-J represses Notch target genes by recruiting a corepressor complex. Notch signaling is dysregulated in many cancers, and faulty notch signaling is implicated in many diseases including CADASIL (Cerebral Autosomal Dominant Arteriopathy with Sub-cortical Infarcts and Leukoencephalopathy), T-ALL (T-cell acute lymphoblastic leukemia), Alagille syndrome, MS (Multiple Sclerosis), and myriad other disease states.

Delta Jagged TACE ADAM Notch Numb NAK alpha- adabtin Fringe Furin Deltex NEDD4 O-Fut CtBP SKIP HDAC SHARP SMRT CSL C1R MAM HAT CSL CDK8 SEL-10 MAM HAT CSL Crumbs NICD HES Myc IL-4 P21 y-secretase Complex Degradation Signal Receiving Cell Signal Sending Cell Endosome Cytoplasm Nucleus N-Glycosylation O-Glycosylation S1 cleavage Persenilin Nicastrin APH1 PEN2

Notch Signaling Pathway from A to Z

ADAM search result
alpha- adabtin search result
APH1 search result
C1R search result
CDK8 search result
Crumbs search result
CSL search result
CtBP search result
Cytoplasm search result
Degradation search result
Degradation search result
Delta search result
Deltex search result
Endosome search result
Endosome search result
ER search result
Fringe search result
Furin search result
Golgi search result
HAT search result
HDAC search result
HES search result
IL-4 search result; Category: IL-4
Jagged search result
MAM search result
Myc search result
NAK search result
NEDD4 search result
N-Glycosylation search result
NICD search result
Notch search result
Nucleus search result
Numb search result
O-Fut search result
O-Glycosylation search result
P21 search result
PEN2 search result
Persenilin search result
S1 cleavage search result
S3 Cleavage search result
SEL-10 search result
SHARP search result
Signal Receiving Cell search result
Signal Sending Cell search result
SKIP search result
SMRT search result
TACE search result
y-secretase Complex search result
Nicastrin search result

Thanks to Sino Biological for providing the pathways.