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BioAim Scientific (Kanada)
The BioAim Mouse SCF EasyTestTM ELISA kit can quantitatively measure SCF in Mouse serum or plasma. It is a simple and rapid technology for the quantitation of antigen in a range of sample matrices. The whole process takes less than 1.5 hours with high accuracy and precision. EasyTestTM ELISA is faster and easier to perform than standard format ELISA with less reagent handling and fewer pipetting steps.Research Area cell proliferation and growth;
Mouse
KIT ligand(SCF) Background: Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Mature human SCF consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 36 aa cytoplasmic tail. The ECD shows both N-linked and O-linked glycosylation. Within the ECD of the short isoform (corresponding to this recombinant protein), human SCF shares 75 – 83% aa sequence identity with canine, feline, mouse, and rat SCF. Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF-R/c-kit to trigger receptor dimerization and signaling. SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels. CF plays a role in the regulation of HSCs in the stem cell niche in the bone marrow. SCF has been shown to increase the survival of HSCs in vitro and contributes to the self-renewal and maintenance of HSCs in-vivo. HSCs at all stages of development express the same levels of the receptor for SCF (c-KIT). The stromal cells that surround HSCs are a component of the stem cell niche, and they release a number of ligands, including SCF.
Clo, Mgf, blz, SCF, SLF, Gb, Sl, Kitlg, contrasted, SF, Con
< 1 pg/ml
20.5-5000 pg/ml
Serum
1x96 Wells
1.5 h
Sandwich ELISA
P20826
Menge | 1x96 Wells |
---|---|
Hersteller | BioAim Scientific |
Herstellerland | Kanada |
Sensitivity | < 1 pg/ml |
Specific Against | Mouse |
Antigen Name | KIT ligand |
Detection Range | 20.5-5000 pg/ml |
Alias | Clo, Mgf, blz, SCF, SLF, Gb, Sl, Kitlg, contrasted, SF, Con |