Mouse IL-1ra EasyTestTM ELISA kit

Brand

BioAim Scientific (Kanada)

short description

The BioAim Mouse IL-1ra EasyTestTM ELISA kit can quantitatively measure IL-1ra in Mouse serum or plasma. It is a simple and rapid technology for the quantitation of antigen in a range of sample matrices. The whole process takes less than 2.5 hours with high accuracy and precision. EasyTestTM ELISA is faster and easier to perform than standard format ELISA with less reagent handling and fewer pipetting steps.
Research Area Inflammation;

specific against

Mouse

detection target

interleukin 1 receptor antagonist(IL-1ra)
Background: IL-1RA is a member of the interleukin 1 cytokine family. IL1Ra is secreted by various types of cells including immune cells, epithelial cells, and adipocytes, and is a natural inhibitor of the pro-inflammatory effect of IL1β. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. Mutations in the IL1RN gene results in a rare disease called deficiency of the interleukin-1–receptor antagonist (DIRA).Variants of the IL1RN gene is also associated with risk of schizophrenia. Elevated levels of IL1RN has been found in serum of schizophrenia patients.

alias

F630041P17Rik, IL-1ra

sensitivity

< 1 pg/ml

detection range

98.3-24000 pg/ml

sample type

Serum

pack size

1x96 Wells

Assay time

2.5 h

Principle of the Elisa

Sandwich ELISA

SwissProtID

P25085