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CD262 Gene ID | 8795 |
---|---|
CD262 Official Full Name | tumor necrosis factor receptor superfamily member 10b |
CD262 Alias | TRAIL-R2, DR5, TNFRSF10B |
CD262 Cellular Expression | T; B; NK; Granulocyte; Macrophage |
CD262 Ligand/Receptor/Association | TRAIL (CD253) |
CD262 Function | Activated by TNFSF10 / TRAIL and transduces apoptosis signal |
CD262 Summary | The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009] |