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Interleukin-10 (IL-10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-Alpha, IL-6 and IL-1 by activated macrophages IL-10 is a pleiotropic cytokine with important immunoregulatory functions. Its actions influence activities of many of the cell-types in the immune system. It is primarily secreted by antigen-presenting cells such as activated T-cells, monocytes, B-cells and macrophages. In biologically functional form, it exists as a homodimer that binds to tetrameric heterodimer IL-10 receptor and induces downstream signaling. IL-10 is associated with survival, proliferation and anti-apoptotic activities of various cancers such as Burkitt lymphoma, non-Hodgkins lymphoma and non-small scell lung cancer.
SINGLE COMPONENTS | PRODUCTS |
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CD14 | search result; Category: CD14 |
Cytokines | search result; Category: Cytokines |
IkB | search result |
IKK | search result |
IL1 | search result; Category: IL1 |
IL10 | search result; Category: IL10 |
IL10R1 | search result; Category: IL10R1 |
IL10R2 | search result; Category: IL10R2 |
IL6 | search result; Category: IL6 |
IL6R | search result; Category: IL6R |
IL6ST | search result; Category: IL6ST |
IRAK1 | search result |
IRAK4 | search result |
JAK1 | search result |
LPS | search result |
MAP3K7 | search result |
Myc | search result |
MYD88 | search result |
NF-kB | search result |
p38 | search result |
PI3K | search result |
SOCS | search result |
STAT3 | search result |
TLR4 | search result |
TNF | search result; Category: TNF |
TRAF6 | search result |
TYK2 | search result |
Jak | search result |
AKT signaling pathway | search result |
P38 MAPK signaling pathway | search result |
Thanks to Sino Biological for providing the pathways.