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IL-10 Signaling Pathways

Interleukin-10 (IL-10) is an anti-inflammatory cytokine with important immunoregulatory functions. It is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-Alpha, IL-6 and IL-1 by activated macrophages IL-10 is a pleiotropic cytokine with important immunoregulatory functions. Its actions influence activities of many of the cell-types in the immune system. It is primarily secreted by antigen-presenting cells such as activated T-cells, monocytes, B-cells and macrophages. In biologically functional form, it exists as a homodimer that binds to tetrameric heterodimer IL-10 receptor and induces downstream signaling. IL-10 is associated with survival, proliferation and anti-apoptotic activities of various cancers such as Burkitt lymphoma, non-Hodgkins lymphoma and non-small scell lung cancer.

IL-10 IL10RA IL10RB IL10RB IL-6 IL6R IL6ST IL6ST Jak Jak STAT3 STAT3 STAT3 STAT3 STAT3 STAT3 STAT3 p38 PI3K SOCS Myc Cytokines IL1 TNF IL6 NF-kB NF-kB IkB IKK MAP3K7 TRAF6 IRAK4 IRAK1 MYD88 LPS TLR4 CD14 JAK1 TYK2 TYK2 AKT signaling pathway P38 MAPK signaling pathway

IL-10 Signaling Pathways from A to Z

CD14 search result; Category: CD14
Cytokines search result; Category: Cytokines
IkB search result
IKK search result
IL1 search result; Category: IL1
IL10 search result; Category: IL10
IL10R1 search result; Category: IL10R1
IL10R2 search result; Category: IL10R2
IL6 search result; Category: IL6
IL6R search result; Category: IL6R
IL6ST search result; Category: IL6ST
IRAK1 search result
IRAK4 search result
JAK1 search result
LPS search result
MAP3K7 search result
Myc search result
MYD88 search result
NF-kB search result
p38 search result
PI3K search result
SOCS search result
STAT3 search result
TLR4 search result
TNF search result; Category: TNF
TRAF6 search result
TYK2 search result
Jak search result
AKT signaling pathway search result
P38 MAPK signaling pathway search result

Thanks to Sino Biological for providing the pathways.