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Human LDL R ELISA Kit

Product Code: BAS-3010240

Verfügbarkeit: Auf Lager

Human LDL R ELISA Kit

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Beschreibung

Details

Human LDL R ELISA Kit

Brand

BioAim Scientific (Kanada)

short description

The Bioaim Human LDL R ELISA kit is a solid phase sandwich ELISA (enzyme-linked immunosorbent assay) for the quantitative measurement of LDL R in Human serum, plasma and cell culture media. An antibody specific for Human LDL R was coated on a 96-well plate. Standards and samples are added to the wells and any LDL R present binds to the immobilized antibody. The wells are washed and biotinylated anti-Human LDL R antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is added to the wells. The wells are again washed and TMB substrate solution is added, which produces a blue color in direct proportion to the amount of LDL R present in the initial sample. The Stop Solution changes the color from blue to yellow, and the microwell absorbances are read at 450 nm.
Research Area Lipid metabolism;

specific against

Human

detection target

low density lipoprotein receptor (LDL R)
Background: LDL R is a widely expressed cell surface scavenger receptor. LDL R binds ApoB and ApoE, the apolipoproteins of low- and very low-density lipoproteins, respectively. It is a cell-surface receptor that recognizes the apoprotein B100, which is embedded in the outer phospholipid layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). It belongs to the Low density lipoprotein receptor gene family. It is most significantly expressed in bronchial epithelial cells and adrenal gland and cortex tissue. Hepatocyte LDL R is responsible for endocytosis and clearing of most plasma LDL cholesterol. At the low pH of the endocytic vesicle, it dissociates, allowing degradation of LDL and recycling of LDL R to the cell surface. Lack of LDL R expression or function causes familial hypercholesterolemia.

alias

FH, FHC, LDLCQ2

sensitivity

4 pg/ml

detection range

8.2-2000 pg/ml

sample type

Serum, plasma, Cell culture supernatant

pack size

1x96 Wells

Assay time

4.5 h

Principle of the Elisa

Sandwich ELISA

SwissProtID

P01130

Weitere Informationen

Weitere Informationen

Menge 1x96 Wells
Hersteller BioAim Scientific
Herstellerland Kanada
Sensitivity 4 pg/ml
Specific Against Human
Antigen Name low density lipoprotein receptor 
Detection Range 8.2-2000 pg/ml
Alias FH, FHC, LDLCQ2
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