Human IP-10 EasyTestTM ELISA kit

Brand

BioAim Scientific (Kanada)

short description

The BioAim Human IP-10 EasyTestTM ELISA kit can quantitatively measure IP-10 in human serum or plasma. It is a simple and rapid technology for the quantitation of antigen in a range of sample matrices. The whole process takes less than 1.5 hours with high accuracy and precision. EasyTestTM ELISA is faster and easier to perform than standard format ELISA with less reagent handling and fewer pipetting steps.
Research Area Angiogenesis; inflammation;

specific against

Human

detection target

chemokine (C-X-C motif) ligand 10(IP-10)
Background: IP-10 was originally identified as an IFN-gamma-inducible gene in monocytes, fibroblasts and endothelial cells. The mouse homolog of human IP-10, CRG-2, shares approximately 67% amino acid sequence identity with human IP-10. The amino acid sequence of IP-10 identified the protein as a member of the CXC chemokine subfamily. CXCL10 is secreted by several cell types in response to IFN-β. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3.

alias

gIP-10, INP10, IP-10, IFI10, SCYB10, crg-2, C7, mob-1

sensitivity

< 1 pg/ml

detection range

40.9-10000 pg/ml

sample type

Serum

pack size

1x96 Wells

Assay time

1.5 h

Principle of the Elisa

Sandwich ELISA

SwissProtID

P02778