BioAim Scientific (Kanada)
The Bioaim Human DLL1 ELISA kit is a solid phase sandwich ELISA (enzyme-linked immunosorbent assay) for the quantitative measurement of DLL1 in Human serum, plasma and cell culture media. An antibody specific for Human DLL1 was coated on a 96-well plate. Standards and samples are added to the wells and any DLL1 present binds to the immobilized antibody. The wells are washed and biotinylated anti-Human DLL1 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is added to the wells. The wells are again washed and TMB substrate solution is added, which produces a blue color in direct proportion to the amount of DLL1 present in the initial sample. The Stop Solution changes the color from blue to yellow, and the microwell absorbances are read at 450 nm.Research Area angiogenesis, cell survival, and the immune response;
delta like canonical Notch ligand 1 (DLL1) Background: DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in central nervous system morphogenesis, intervertebral joint formation, inner ear hair cell development and patterning, and arteriogenesis. It regulates the homeostasis and differentiation of neural, pancreatic, and myogenic progenitor cells, T and B lymphocytes. DLL1 is overexpressed in a number of cancers and contributes to tumorigenesis. The extracellular region of DLL1 can be shed from the cell surface, and the intracellular domain can be cleaved by gamma-secretase to translocate to the nucleus and regulate gene transcription. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.
DELTA1, DL1, Delta
Serum, plasma, Cell culture supernatant
|Antigen Name||delta like canonical Notch ligand 1|
|Detection Range||49.2-12000 pg/ml|
|Alias||DELTA1, DL1, Delta|